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Acknowledgments The authors sincerely thank the Department of Product Evaluation (Shanghai Jiyan Biomedical Development Co., Ltd.) for their technical support in skin experiments

Single-cell sequencing (CITE-seq): preparation, pre-processing, and analysis For CITE-seq labelling, a total of 2 million cells/genotype were FACS sorted, counted, isolated, and spun down

The next experimental step included extracting total RNA from the cells through the use of the acid guanidinium thiocyanate-phenol-chloroform extraction method

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We will give specific instructions for missed doses, so you do not double-dose or disrupt the titration plan