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Sensitivity analyses were conducted in patients with at least two prescriptions for pre-switch GLP-1 RA

The investigational triple agonist retatrutide is in Phase 3 trials with dosage regimens still being optimized

4.3% of adults taking semaglutide vs 0.7% on placebo quit the trial because of gastrointestinal issues

As a result, glucose-dependent insulin secretion may be supported, glucagon release may be reduced, and gastric emptying may be slowed down

Lead investigator Ania Jastreboff, professor of medicine and paediatrics at the Yale School of Medicine, said that clear improvements in assessed cardiometabolic health measures were also recorded during the study