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The main incretin hormones secreted by the epithelial cells of the gastrointestinal track are glucagon-like peptide-1 (GLP)-1 and glucose-dependent insulinotropic peptide, also known as Gastric Inhibitory Polypeptide (GIP), which stimulate the pancreatic cells ( and cells) and regulate insulin secretion with respect to blood glucose concentration (Drucker, 2006)
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How Tirzepatide Works Tirzepatide is a dual GIP and GLP-1 receptor agonist a single peptide that activates both incretin receptors at once
Medicare and most insurance do not cover GLP-1s for weight loss
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