We recently reported that NNMTi treatment combined with a low-fat, or lean, diet (LD) returned systemic adiposity and liver pathologies of obese animals to the adiposity and liver pathology levels of LD controls
By inhibiting NNMT, the body maintains higher NAD levels, which in turn activate SIRT1, a longevity-associated gene, which may improve mitochondrial activity, fat oxidation, insulin sensitivity, and by overall energy balance
In rare cases, B12 injections can cause more serious side effects
Without it, RBC precursors grow abnormally large (megaloblasts) and fail to mature
This skin darkening is generally reversible with the help of B12 shots