GIP/GLP-1 receptor agonist Tirzepatide for type 2 diabetes and obesity
The application alleges liability as manufacturer of Novo Nordisk for the safety defect of the drugs Ozempic and Rybelsus in that there was a lack of sufficient indications as to the health risks and dangers they involve or as to the means to avoid them, in particular the risks of gallbladder disorders, severe gastrointestinal injuries (including gastroparesis, or stomach paralysis), blood clots, aspiration during surgery, necrotizing pancreatitis, malnutrition, and vision loss (non-arteritic anterior ischemic optic neuropathy)
RWE as a complement to CVOTs SGLT2 inhibitor CVOTs such as EMPA-REG OUTCOME have yielded impressive results, with HHF reductions across the class and CV death outcomes with empagliflozin carrying sufficient weight to influence major international diabetology and cardiology guidelines [1,2,3,4,5,6]
This episode is a must-listen for anyone looking to better understand MCAS and the challenges surrounding its diagnosis and care
Absence of acute toxicity does not establish absence of carcinogenic potential