For most people with a vitamin B12 deficiency, oral supplements are an effective way to bring your levels up to normal, says Foxx, and research backs this up (2)
Crohns disease Those with Crohns disease may suffer from Vitamin B12 deficiency because of a surgery that makes it difficult for orally administered Vitamin B12 to get absorbed in the body after the digestive system is operated upon
So, if you're feeling unwell due to a deficiency, restoring B12 levels might help you feel well enough to eat normally, but it's not "making" you gain weight in an unhealthy way
According to the NIH Office of Dietary Supplements, functional B12 deficiency is most commonly seen in patients with one or more of the following: Age over 50 stomach acid production declines with age, and stomach acid is required to free B12 from food PPI or H2 blocker use reflux medications suppress the acid needed for B12 absorption Metformin use, which interferes with B12 absorption directly Vegan or vegetarian diets B12 is found almost exclusively in animal products Gut conditions including celiac, IBS, SIBO, and Crohns MTHFR mutations that affect how B12 is metabolized once absorbed Heavy alcohol use The symptoms of low B12 are easy to dismiss: fatigue, brain fog, low mood, tingling in the hands or feet, weakness, and shortness of breath on mild exertion
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