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Patients should take steps to be as hydrated as possible, especially when suffering gastric side effects like vomiting or diarrhea
Community-reported protocols start at 0.250.5 mg/week and titrate to 1.54 mg/week over 812 weeks as GI tolerance is assessed
Discontinuation of GLP1RAs and tirzepatide can also result in a loss of the beneficial anti-atherosclerotic and plaque-stabilizing effects of these medications
Semaglutide's gastrointestinal effects vary by product and dose: nausea (20-44%), vomiting (9-24%), and diarrhea (9-30%) according to FDA prescribing information
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