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They work by inhibiting tyrosinase activity, which reduces melanin production, and by shifting melanin production from darker eumelanin to lighter pheomelanin

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Published in NEJM 2023

Retatrutide acts on: GLP-1 GIP Glucagon receptors This triple agonism means retatrutide potentially: Reduces appetite (GLP-1) Improves insulin signalling (GIP) Increases energy expenditure (glucagon) Semaglutide primarily reduces calorie intake

Do not use the pen without proper training from a healthcare professional