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Damage to the kidney is more prevalent in users with pre-existing renal disease or those taking other medications that affect kidney function

Another study reported the interplay between ROS and SIRT1 in cell death during EV71 infection, and inhibition of ROS by NAC was shown to reduce EV71 propagation 149

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it manifests as a spectrum of clinical conditions dominated by candidemia, and can further develop into disseminated infections involving multiple deep organs such as the kidneys, liver and heart valves, with non-specific clinical symptoms and an attributable mortality rate of approximately 30% (Pappas et al., 2018)