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Discovery and development of exenatide: the first antidiabetic agent to leverage the multiple benefits of the incretin hormone, GLP-1

10.1016/j.cell.2015.05.056 108 WuC.-Y.YangY.-H.LinY.-S.ChangG.-H.TsaiM.-S.HsuC.-M.et al (2021)

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In simpler terms: the molecule is engineered to mimic the portion of growth hormone that appears to drive fat metabolism (lipolysis, fat breakdown) without engaging the full spectrum of growth hormone effects (such as stimulating insulin-like growth factor 1 (IGF-1) or promoting generalized tissue growth)