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GAMP 5 principles for risk-based validation of computerized systems provide a foundation for AI change control, though adaptation is required for LLM non-determinism [ISPE GAMP 5, 2022] ( Discussion This narrative review has examined the current landscape of LLM applications in healthcare quality management, revealing a field rich in potential but constrained by significant implementation challenges

For example, California, citing budget constraints, put Wegovy on a waiting list and limited it only to patients with certain co-conditions while studying overall impact

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