Kawasaki, R., Tsuchiya, K., Kodama, Y
Different subregions of the VTA receive glutamatergic inputs from the prefrontal cortex, orexinergic inputs from the lateral hypothalamus, cholinergic and also glutamatergic and GABAergic inputs from the laterodorsal tegmental nucleus and pedunculopontine nucleus, noradrenergic inputs from the locus ceruleus, serotonergic inputs from the raphe nuclei, and GABAergic inputs from the nucleus accumbens and ventral pallidum
4.5 Expanded epigenetic regulation: PRMT5 inhibition Beyond its established HDAC inhibitory activity, SFN demonstrates additional epigenetic modulation through inhibition of protein arginine methyltransferase 5 (PRMT5)
For the broader picture of which peptides already have FDA approval, see our FDA Approved Peptides List 2026
And the timing isnt a coincidence