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Fe 3+ is subsequently reduced to Fe 2+ by the metalloreductase six-transmembrane epithelial antigen of the prostate 3 (STEAP3), followed by its transport into the cytosol via DMT1 to join the labile iron pool (LIP) or be stored in ferritin (Yan et al., 2021

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The presence of a drug affinity complex (DAC) moiety, linked via N-epsilon-3-maleimidopropionamide to the C-terminal lysine, may further stabilize plasma exposure while maintaining GHRH receptor affinity comparable to the native ligand

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