aspirin and semaglutide New in the September 18, 2025, issue of NEJM: ⁣ ⁣ for PI3K-Altered Localized Colorectal Cancer (ALASCCA phase 3 trial) ⁣ ⁣ Orforglipron in Early Type 2 Diabetes (ACHIEVE-1 phase 3 #418 DIGEST (Tofurkey Edition)

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Its not clear what the link is between these drugs and suicidal thoughts, but its assumed the neuropsychiatric side effects emerge when semaglutide interacts with the brain to control appetite

Medicinal Research Reviews , 42 (3), 13431371

A therapeutic formulation was also marketed for pediatric growth hormone deficiency (GHD)

Most people tracking their GLP-1 journey face the same challenge: distinguishing what's working, what's inconsistent, and what's causing the changes they experience