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A 2024 review in BioImpacts synthesizing the topical GHK-Cu evidence concluded that the peptide has consistent anti-wrinkle and skin-rejuvenating activity in human studies, though formulation and delivery remain ongoing challenges [5]
Only clinical study designs (S)randomised controlled trials (RCTs), non-RCTs, cohort, or case-control studieswere included
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Additionally, the pre-exposure with GHK-Cu was posited to decrease i-NOS levels through the NF-B pathway, linking it further to anti-inflammatory processes
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