The enzyme dipeptidyl peptidase-4 (DPP-4) destroys GLP-1 almost as fast as the body produces it
[14] successfully isolated exendin-4 from the venom of the Gila monster (Heloderma suspectum), a lizard known for its infrequent but large meals weighing up to as much as one third of its body masssuggesting the presence of adaptive metabolic mechanisms in the species [14,15]
In these very high-risk patients, SGLT-2 inhibitors reduce overall mortality with a number needed to treat (NNT) of 25 (95% CI, 18 to 48) over five years
doi: Mielgo-Ayuso, J., Pietrantonio, L., Viribay, A., Calleja-Gonzlez, J., Gonzlez-Bernal, J
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