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However, neurotrophins have had little success in clinical trials directed at neurodegenerative diseases due to their poor pharmokinetic profile and large molecular weight that significantly impedes penetration of the BBB [61,62]
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Recent in vitro and animal studies have indicated an association between elevated homocysteine (Hcy) levels and the formation of reactive oxygen species, especially the superoxide anion (O 2 ) and H 2 O 2 ( Reference Huang, Hsu and Lin 8 Reference Weiss 10 ) , by the auto-oxidation of Hcy and/or cysteine ( Reference Hogg 11 )
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