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The NLRP3 inflammasome is activated by lipid peroxidation byproducts such as 4-HNE and MDA produced during ferroptosis, triggering caspase-1-dependent maturation of IL-1/IL-18, which amplifies inflammation and establishes a vicious cycle (127, 131)
It has a smaller community and less published clinical outcome data than more established providers
Additionally, assessment and control of other risk factors (e.g., sleep apnea) may be considered prior to or concurrent with initiation of semaglutide or tirzepatide treatment, Krauss added.
Lake JE et al
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