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PubMed Rai G, Wright G, Scott L, et al

In hepatocytes and adipocytes it reduces the activity of key lipogenic enzymes: Acetyl-CoA carboxylase (ACC) , a key step in fatty acid synthesis Fatty acid synthase (FAS) , the enzyme creating long chains of fatty acids Lipoprotein lipase (LPL) in adipocytes, reduces uptake of circulating triglycerides into fat cells Imagine it as turning valves in a pipeline, you close the inflow (lipogenesis), open the outflow (lipolysis)

For this article, best is evaluated across five criteria that matter to real people pursuing real fat loss outcomes: Total body weight reduction: The percentage of baseline body weight lost over a standardized time period

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