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Nrf2 depletion in macrophages leads to increased foam cell formation, increases the M1 inflammatory phenotype with enhanced expression of pro-inflammatory monocyte chemoattractant protein-1 and interleukin-6, and aggravates atherosclerosis (244, 245)

Wada, T

Clogging up your coronary arteries with cholesterol is a leading cause of congestive heart failure (ischemic heart disease), but there are other causes (COPD, emphysema etc.)

In this study, it was assumed that using the auto-reduction of the hydroquinone adjacent to the quinone on doxorubicin was a sufficient indicator of the rate of oxidation of a potential redox cycle, either on the hydroquinone or the quinone after reduction

doi: 10.1038/nature04186 193 JonesD