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Dual PI3K/mTOR inhibitor PKI-402 suppresses the growth of ovarian cancer cells by degradation of Mcl-1 through autophagy

The study employed advanced analytical methods, such as UPLC-MS for plasma samples and HPLC with fluorometric detection for erythrocytes, to measure GSH and related compounds accurately, given their low concentrations

Human studies remain limited compared to animal research

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In the current study, 4/18 (22%) not detected samples were classified as 1d, 1e, 1g, and 1h by sequencing, while the proportion of non-1a non-1b subtypes was higher in the study by Mokhtari et al