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Certain vitamin and mineral deficiencies can also affect antioxidant systems more broadly

This includes oral medications like metformin or insulin secretagogue, such as sulfonylureas

Fujitsuka N, Asakawa A, Uezono Y, Minami K, Yamaguchi T, Niijima A, Yada T, Maejima Y, Sedbazar U, Sakai T, Hattori T, Kase Y, Inui A

GLP-1 receptor agonists (GLP-1RAs) have the potential to reduce these risk factors, but their role in lymphedema has never been investigated

This mechanism ensures that large amounts of ATP are formed only at high glucose levels (Glc transporter SLC2A2 is active at higher levels, normal Glc level is 3.6 - 5.5 mmol/l)