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doi: 10.3389/fncel.2022.889765, 20 ChenK

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It is important to seek urgent medical help (via NHS 111, urgent care, or A&E as appropriate) if you experience severe, persistent abdominal pain (especially if radiating to the back, which may indicate pancreatitis), jaundice/fever/right upper quadrant pain (possible gallbladder disease), inability to keep fluids down, minimal urine output, or signs of dehydration such as dark urine or dizziness