does semaglutide lose efficacy over time Long-term kidney outcomes of in obesity and cardiovascular disease in the SELECT trial 🥼🧪Slide Deck: Efficacy and safety

It is derived from coconut oil

In recent years, GLP-1 approvals have expanded beyond blood sugar management and weight loss to include other organs, like the heart, kidneys, and liver

Diabetes 44:14611466 Kirschner LS, Kuzewitt DF, Matyakhina L, Towns WH 2nd, Carney JA, Westphal H, Stratakis CA (2005) A mouse model for the Carney complex tumor syndrome develops neoplasia in AMP-responsive tissues

This deactivation of MKPs allows for the unimpeded progression and sustained activation of the pro-inflammatory ERK1/2, JNK, and p38 signaling cascade within the MAPK pathway (Son et al., 2011)

Some dialysis patients may be candidates for GLP-1 medications, while others may not tolerate them well