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Moreover, GLP-1RA reduced the risk of MACE by 14% in the overall diabetic population, with an apparent greater effect in patients with established CV disease (16% vs 6% reduction, respectively), although the lack of significant interaction between subgroups does not allow to separate them [12]

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Indeed, the mutation P478L of OCTN2, abolished only the carnitine transport activity (Seth et al., 1999)

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The extra receptor target may translate to greater weight loss potential and more robust metabolic improvements for certain individuals

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