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Safety Considerations Vitamin B12 supplements are generally safe, even in high doses, because your body doesn't absorb the full amount

What is missing There is no published human pharmacokinetic study of subcutaneous AOD-9604, no published human topical or intranasal exposure data, no Phase 3 efficacy trial, no long-term safety data beyond 24 weeks, and no published human cartilage or joint outcome data

Within minutes of the infusion, the patients reportedly experienced nausea, vomiting, lightheadedness, chills, body aches and sneezing

Regional distribution of mutations of the ATP7B gene in patients with Wilson disease: impact on genetic testing

(Pereaez et al., 2013