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AAR is also supported by the UK Medical Research Council (MR/N026101/1, MR/R025134/1, MR/S009434/1, MR/S036784/1, and MR/T044853/1), Wellcome Trust Institutional Strategic Support Fund/UCL Therapeutic Acceleration Support (TAS) Fund (204841/Z/16/Z), European Unions Horizon 2020 research and innovation programme under grant agreement no

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A375 cells transduced with empty vector control (Ctrl) or shRNA targeting both GNAQ and GNA11 (shGq/11) were treated with vehicle or trametinib for 72 h