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Since the diversity of gut microbiota erodes during aging, dysbiosis could also be a reason for high susceptibility of older adults to severe COVID-19 248

Some researchers have hypothesized potential applications in: Stroke recovery and neural repair Traumatic brain injury Parkinsons disease where the HGF/c-Met system has its own preclinical literature and the fosgonimeton SHAPE Phase 2 trial in Parkinsons disease dementia produced an exploratory cognitive signal Age-related cognitive decline (prevention rather than treatment) Frontotemporal dementia (FTD) the young-onset dementia where the October 2025 Alector latozinemab Phase 3 INFRONT-3 failure (sustained 2-fold plasma progranulin rise without clinical benefit) is the FTD analog of the EVOKE / EVOKE+ Alzheimers pattern, and where Vesper Bio VES001, Denali DNL593 and Passage Bio PBFT02 are the 2026 progranulin-pathway readouts Vascular dementia (VaD) & vascular cognitive impairment (VCI) the 2nd-most-common dementia (~150,000 UK cases, 17% of all dementia) and the most-frequent mixed-pathology partner of Alzheimers in autopsy series, with the April 2026 UCLA brain-repair breakthrough, UNSW CHeBA Mendelian-randomization genetics (APOE, TOMM40, ERAP, SAA1-4) and the HGF/c-Met angiogenesis / blood-brain-barrier biology making it arguably the cleanest mechanistic fit for a synaptogenic peptide on this site Dementia with Lewy bodies (DLB) & Parkinsons disease dementia (PDD) the 3rd-most-common dementia (~100,000 UK cases, 10-15% of all dementia) and a frequent Alzheimers co-pathology partner, with the December 2025 CervoMed neflamapimod RewinD-LB extension success, the April 2026 AAN basal-forebrain MRI volume and functional-connectivity signal, FDA-aligned 300-patient Phase 3 starting H2 2026, the Norwegian ANeED ambroxol Phase IIa GBA1-chaperone trial and the maturation of alpha-synuclein seed-amplification assays (aSyn-SAA / RT-QuIC) as a living biomarker backbone for the alpha-synucleinopathies Type 2 diabetes brain fog & diabetic cognitive impairment where the type-3-diabetes overlap with Alzheimers, brain insulin resistance and the EVOKE / EVOKE+ semaglutide Phase 3 failure of 2026 directly intersect with the Alzheimers evidence base Dihexa & GLP-1 Drugs (Ozempic, Wegovy, Mounjaro) and the Brain the wider GLP-1 brain-health, cognition and dementia-risk review across semaglutide / tirzepatide / liraglutide / exenatide: the November 2025 EVOKE / EVOKE+ Phase 3 failure in detail and the AD/PD 2026 readout

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Obesity, high-fat diets, and high-sugar diets have all been associated with reproducible gut microbiome modifications (8082)