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In December 2025 the FDA approved the 25 mg oral semaglutide dose (oral Wegovy) specifically for chronic weight management, making it the first oral GLP-1 approved for obesity

Physical therapy represents the most valuable complementary treatment

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Regular exercise, fresh air, mindfulness, a peaceful environment, deep breathing and other self-care exercises can also help minimize headache symptoms

Early-phase human trials are small, well-controlled studies centered on safety, reproductive hormones, and surrogate markers such as ovarian reserve tests and sperm parameters ahead of any efficacy trials