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Additionally, it corroborated the amino acid dysregulation, evidencing a downregulation of valine and an upregulation of serine, leucine, and lysine in the pathological tissue

They promote lipid, protein, and DNA oxidation, forming cytotoxic products such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), which compromise mitochondrial DNA and disrupt electron transport, especially at complexes I and III (Wang et al., 2024)

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With GSH depleted, IKK becomes constitutively active, driving continuous transcription of TNF-, IL-6, and IL-1

Oral challenges should only be performed under medical supervision so that emergency treatment can be prescribed if anaphylaxis occurs