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A 2025 systematic review in orthopaedic sports medicine noted that most evidence remains preclinical, but the peptide showed promising findings in muscle, tendon, ligament, and bony injury models

There was no statistical heterogeneity overall (I 2 = 0) or between diagnoses (I 2 = 0) for plasma glycine

(PubMed) Food and Nutrition Board, Institute of Medicine

The current once-weekly subcutaneous injection model works, but once-monthly or even implantable formulations are on the horizon

In autonomic regulation, DCA initially reduces heart rate via reflex mechanisms but subsequently activates sympathetic pathways to maintain HR