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Common Causes of B12 Deficiency Vitamin B12 deficiency can happen for many reasons

No endorsement implies FDA approval or confirmed human efficacy
Biofactors 19 , 145153 (2003)
Your B12 shot frequency matters so much because B12 is water-soluble, so any excess is excreted within hours
Biochim Biophys Acta Mol Cell Biol Lipids 1862:623635

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