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Zepbound Data as Reported by Lilly The manufacturers language on the weight loss indication reads thus: Zepbound is indicated in combination with a reduced-calorie diet and increased physical activity: to reduce excess body weight and maintain weight reduction long term in adults with obesity or adults with overweight in the presence of at least one weight-related comorbid condition. At 72 weeks, patients taking Zepbound 15mg lost an average of 20.9% of their body weight