If inflammation remains excessive and unmanaged, the repair environment remains chaotic
This peroxidation occurs via two major pathways: the enzymatic pathway, mediated by lipoxygenases (LOXs), cytochrome P450 oxidoreductase (POR), and NADPH oxidases (NOXs), promotes the generation of PUFA-PL-OOHs, leading to the accumulation of reactive aldehydes, ketones, and other toxic metabolites, ultimately disrupting membrane integrity and triggering ferroptosis (Maheshwari, 2023)
Clinical studies have generally shown good tolerance at recommended doses, with most adverse effects being mild and transient
Gut Health: Given its origin, it's no surprise that a massive body of research centers on its protective effects on the gastrointestinal tract, from the esophagus to the colon
Pitavastatin prevents NMDA-induced retinal ganglion cell death by suppressing leukocyte recruitment