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GLP-1 GLP-1Glucagon-like peptide-1-1 (Incretin) GLP-1GLP-1 GLP-1 (Glucagon-like peptide-1) (Glucagon) GLP-1 (Proglucagon) PC2 (Prohormone Convertase 2) (Glucagon) L PC1/3 (Prohormone Convertase 1/3) GLP-1 GLP-2 Alignment (Sequence Identity) 50% N (N-terminus) 9 7 GLP-1 N C GLP-1 GLP-1GLP-1GLP-1 GLP-1 DPP-4 2 / STEP SURMOUNT GLP-1 (Gila monster Heloderma suspectum ) 1990 John Eng Exendin-4 Exendin-4 GLP-1 50% Exendin-4 GLP-1 2 Exendin-4 2 AlanineGlycine () Exendin-4 DPP-4 Exendin-4 Exendin-4 GLP-1 (Exenatide) (Byetta) 2005 PeptaibolsAib Aibalpha-aminoisobutyric acidalpha- 2-aminoisobutyric acid 2-methylalanineAibalpha- (-CH)alpha-Gem-dimethyl group GLP-18AibGLP-1 DPP-4 Aib Alpha- (Alpha-helix) Alpha-GLP-1 Aib GLP-1SemaglutideAib262 (Saxenda) (Ozempic) (Wegovy) (Mounjaro) GIP/GLP-1 Tirzepatide GLP-1 STEP-1 68 17% GLP-1 GLP-1 (Sarcopenia) (Gastroparesis) 20-40% (Gastroparesis) (Medullary Thyroid Cancer) (Pancreatitis) GLP-1