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542 Although tau protein aggregation and beta-amyloid protein (A) accumulation play central roles in the pathophysiological hypothesis of AD, the potential role of metal overload, subsequent oxidative stress, and tissue damage cannot be ignored

doi:10.1001/archfaci.8.4.252 Leyden J, Stephens TJ, Finkey MB, Barkovic S

However, it has no effect on the level of GPX4 [247]

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In a randomized controlled trial, a highly bioavailable form of curcumin was found to be as effective as the standard antidepressant medication fluoxetine (Prozac) in the treatment of major depressive disorder (Sanmukhani 2014