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ITPPs action appears to be pH-dependent, showing greater activity in acidic, hypoxic environments, such as ischemic myocardium, while having minimal effect in well-oxygenated, alkaline tissues (Figure 2 for details)

The more energy required for a chemical activity, the more ATP molecules must be spent

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Acetyl-L-carnitine is given intravenously (by IV) for alcohol withdrawal, nerve pain caused by antiviral drugs used to treat HIV, dementia, and reduced blood flow in the brain

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