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38,39 Glutamine traverses the plasma membrane via amino acid transporter type 2 (ASCT2) and sodium-coupled neutral amino acid transporter 5 (SN2), where cytosolic glutaminase converts it to glutamate and then to -ketoglutarate (-KG), which enters the TCA cycle

Huang S-J, Lin C-P, Tsai S-Y

Phase 3 TRIUMPH Program (Ongoing) - LIVER AS SECONDARY ENDPOINT Status: Currently ongoing, results expected 2026 TRIUMPH-4 (Completed December 2025): Primary endpoints: Weight loss + osteoarthritis pain Results: 28.7% weight loss at 68 weeks Liver outcomes: Secondary/exploratory endpoints TRIUMPH-2 (Ongoing, expected 2026): Weight loss in obesity + type 2 diabetes Liver outcomes: Secondary endpoints (liver enzymes, possibly imaging) Key Point: TRIUMPH Phase 3 trials are NOT primarily liver-focused

Consequently, research teams often rely on documented procedures that support repeatability, organization, and scientific consistency throughout the investigative process

La disfuncin orgnica inducida por deficiencia de colina tambin se ha asociado con un aumento del dao en el ADN y la apoptosis en los linfocitos circulantes (15)