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Recommended For: Women in the perimenopause transition (typically age 40-55, but everyone is different!)

How these medications cause weight loss when combined is still somewhat of a mystery, but experts theorize that the combo touches the brains reward centers: Bupropion affects the pathways of two neurotransmitters, dopamine and norepinephrine, which are used in brain areas that process appetite and reward, and naltrexone tends to boost and reinforce this effect, Maselli says

Evidence classification indicated that three outcomes were Class I (3%), one outcome was Class II (1%), 13 outcomes were Class III (13%), 23 were Class IV (23%), and the rest were NS

In early comparisons, a leading dual-receptor peptide reduced body weight by about 20%, which is already a massive effect

In both cases, symptoms improved after the medication was discontinued