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PMC11559783 Comparative Effectiveness and Safety of Oral Versus Subcutaneous Semaglutide

Further evidence supporting this hypothesis comes from the typical decrease in bone turnover observed after oral glucose intake, which is inhibited by infusion of octreotide, a somatostatin analog that suppresses the secretion of gastrointestinal and pancreatic peptides [43]

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Lower doses may not achieve the receptor activation required for meaningful clinical benefit

For many, these drugs offer a powerful starting point to trimming their waistlines but not a complete path to long-term health