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A randomized, parallel-group, multicenter, phase 3 trial found that tirzepatide caused pancreatitis (5 mg n = 3, 10 mg n = 2, 15 mg n = 1) in patients with type 2 diabetes mellitus (Del Prato et al., 2021), and another double-blind, randomized, multicenter, phase 3 trial found that tirzepatide also caused pancreatitis (15 mg n = 2) in obese patients with type 2 diabetes mellitus (Garvey et al., 2023)

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Lesions can occur more rarely in the nasopharynx (5.5%), the parotid gland (2.9%), and to a lesser extent, in the anorectal and vulvovaginal regions and the urinary tract [32]