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For this reason, several novel NBDHEX analogues, with improved selectivity for GSTP1-1, have been synthesized and characterized to obtain new therapeutic opportunities for the treatment of drug resistant tumors including human melanoma 100,101

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If the muscle is sore or tense, use heatapply a heating pad on a low setting, or stand in the shower with a gentle stream of warm water spraying the twitching muscle.Use cold therapy if the twitch includes acute painwrap the muscle in a towel and [10] Limit hot and cold treatments to 15-20 minutes at a time (repeating every 2 hours if needed)

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