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Key Takeaways Glutathione is the bodys master antioxidant crucial for immune defense, detoxification, and maintaining a balanced gut microbiome

Unlike apoptosis, its execution is independent of caspases and is instead driven by receptor-interacting protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3), with mixed lineage kinase domain-like protein (MLKL) acting as the executioner by oligomerizing and forming pores in the plasma membrane, leading to its rupture (41)

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In rare instances, GLP-1 drugs can cause more serious side effects

ER: While glutathione keeps the lights on in the mitochondria, its primary job in the ER is quality control. First Visual Evidence: Working with Memorial Sloan Kettering, the team was able to visualize exactly how the SLC33A1 protein binds and moves its cargo across the ER membrane