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McIntyre, MD, FRCPC Key Takeaways Incretin-based treatments, especially GLP-1 RAs, may address comorbidities in mental disorders and have direct CNS effects, potentially modifying disease progression
In large obesity trials using full doses, once-weekly semaglutide and tirzepatide led to substantial average weight loss and improved metabolic markers in adults with obesity.[13] For example, the STEP 1 trial of once-weekly semaglutide in adults with overweight or obesity and the SURMOUNT-1 tirzepatide obesity trial both showed strong weight-loss effects when combined with lifestyle changes
We also pay attention to selenium, a trace mineral that acts as a critical cofactor for glutathione peroxidase
Rare but serious risks include pancreatitis and gallbladder disease
GPX4-GSH-cysteine axis protectors include selenium supplements and NAC, which together enhance the anti-ferroptosis effect of the GPX4-GSH-cysteine axis
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