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Hippocampal BICD2 knockout in CUMS mouse models of depression shows an antidepressant effect, which may be mediated by increased BDNF expression 133
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88 More broadly, this highlights an underappreciated principle in the field: ferroptotic propagation is shaped not only by intracellular biochemistry but also by tissue-scale geometry and extracellular spatial constraints, linking molecular reactions to anatomical structure
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