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These companies, along with the FDA, are actively working to shut down the marketing and sale of compounded GLP-1s

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The brain pathway may be more significant than the endocrine route for the physiological effects of GLP-1, especially regarding insulin release, but the endocrine route becomes more pronounced with bigger meals and more L-cell activation (Deacon 2019)

The FDA typically takes 6-12 months to review a standard NDA, though priority review (possible with Breakthrough Therapy status) could shorten that

Most people start with around 200-400 mcg per day, but this can vary depending on your goals and needs