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Like cisplatin, it contains two chloride ligands, which are released within the cellular environment and interact with DNA to form intra- and interstrand cross-links.3 These DNA adducts trigger multiple cellular responses, including DNA damage recognition and repair, cell cycle arrest, and activation of apoptotic signaling pathways, ultimately inhibiting cell proliferation.4 Ovarian cancer remains one of the leading causes of mortality among gynecological malignancies, with epithelial ovarian carcinoma accounting for more than 90% of all cases.5 The current standard therapy involves primary cytoreductive surgery followed by platinum-based combination chemotherapy administered as soon as possible after surgery.6 However, a major limitation of these treatments is the dose-dependent toxicity associated with platinum compounds, which can result in significant off-target tissue injury.7 It is well established that Reactive Oxygen Species (ROS) generated during the metabolism of platinum-based agents contribute to this toxicity, particularly in the reproductive system
Even if we were to bring down the cost of these drugs substantially, they would not be cost-saving
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Here is how to think about it: What is normal during titration Mild nausea that comes and goes, especially in the first 35 days after a dose increase Reduced appetite this is the medication working as intended Occasional loose stools or minor constipation Mild fatigue or low energy as your caloric intake decreases Slight bloating or feeling full faster than usual These effects are typically self-limiting
