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Subsequent oxidative stress results in the age-dependent peroxidation of proteins, lipids, and nucleic acids by intracellular mitochondria, destruction of the mitochondrial membrane permeability, and reduction of oxygen respiratory chain activity, leading to an increase in the number of active oxygen species (Oveland et al., 2012
doi: Sarzi-Puttini, P., Giorgi, V., Di Lascio, S
(2016), Indian Dermatology Online Journal , reviewed glutathione's proposed mechanisms and use in skin lightening, noting that while plausible biologically, larger and longer-term trials are still needed
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