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The customized brackets and wires apply gentler, more precise pressure to the teeth, which can reduce discomfort commonly associated with traditional braces

"The combined effect can lower blood sugar too much, which may lead to hypoglycemia," Jung-Im Shin, MD, PhD, an associate professor of epidemiology at the Johns Hopkins Bloomberg School of Public Health, told Health

However, when combined with insulin or sulfonylureas, the risk of hypoglycemia increases substantially, potentially affecting twenty to thirty percent of patients if doses of concurrent medications are not appropriately adjusted

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An atlas is available to facilitate the visual diagnosis of Hunner lesions, since variations in cystoscopic appearance have been reported