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If the clinical profile is additive rather than conflicting, this becomes an interesting scientific data point - GCGR antagonism plus GIP/GLP-1 agonism recovers the diabetes-lowering benefit the antagonist era sought while preserving the incretin-driven appetite effect

doi: 10.1056/NEJMoa2108269 16 DaviesMJD'AlessioDAFradkinJKernanWNMathieuCMingroneGet al

However, as with any form of medication or therapy, there is always the possibility of experiencing side effects

It's easier to eat something healthy when you don't need to eat as often or as much to sate your hunger

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